Advanced tissue engineering for in vitro drug safety testing
نویسندگان
چکیده
Abstract The FDA modernization act 2.0, signed into law by President Biden in December 2022 encourages the use of alternatives to animal testing for drug discovery. Cell-based assays are one important alternative, however they currently not fit purpose. 3D, tissue engineered models represents a key development opportunity, enable human tissues and organs. However, much remains be done terms understanding materials, both bioderived synthetic that can incorporated models, provide structural support also functional readouts. This perspective provides an overview on history safety testing, with brief origins Food Drug Administration (FDA). It then goes discuss current status outlining some limitations models. In vitro , cell-based discussed as alternative parts discovery process, foray beginnings culture comparison 2D vs 3D cell culture. Finally, this lays out argument implementing engineering methods testing. Graphical abstract is long expensive process. Advanced, (human) such organ-on-chip spheroids or organoids, higher throughput used complement, sometimes replace, used. Made biorender.com
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ژورنال
عنوان ژورنال: MRS Communications
سال: 2023
ISSN: ['2159-6867', '2159-6859']
DOI: https://doi.org/10.1557/s43579-023-00421-7